Panel discussion on...
Beauty from within and holistic trends
Trisha Sugarek MacDonald, PhD, MS
Market Development Manager
Akay Bioactives, an Oterra company

Member of AgroFOOD Industry Hi Tech's Scientific Advisory Board

Questions
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The New Era of Beauty Claims
Where do you see the next cycle of beauty claims heading? What specific benefits are consumers searching for today, and where do you predict the market will move over the next five years? Any exciting innovations you want to share in this regard?
The intersection of GLP-1 with Hair & Skin
With the global rise of GLP-1 weight-loss medications, consumers are experiencing rapid metabolic shifts that often trigger hair loss and "Ozempic skin". How do you see the nutricosmetic segment evolving to support the intersection of beauty and weight management/metabolic health?
Holistic Beauty & The "Well-Beauty" Journey
Real beauty isn't just skin deep. What innovations are you developing to bridge beauty and wellness (e.g., neuro-beauty, mood/stress support, beauty sleep, or the gut-skin axis)? Which ingredients or concepts are currently shifting from other health categories into the nutricosmetic space?
Redefining Beauty Rituals
Topical beauty influencers have set a high bar for self-care beauty rituals—how is the nutricosmetic segment catching up? From delivery formats and flavor profiles to fragrance and texture, what is needed to evolve ingestible solutions into a truly joyful daily ritual? And where do you experience the most challenge in this respect?
The K-Beauty Influence
South Korean trends continue to redefine topical skincare. How are these K-Beauty principles being translated into the nutricosmetic industry?
Integrated "In & Out" Journeys
We are moving away from isolated products toward "integrated journeys." What evidence supports the superior efficacy of oral-topical pairings? Furthermore, how can nutricosmetics be better integrated into the dermatology space, accompanying at-home or in-clinic procedures? Is there a difference between different regions in the world?
Nutricosmetics as a Platform for Inclusivity
Skin is the most visible representation of our diversity. How do you research, develop, and market ingredients in a way that thoughtfully addresses differences in gender, ethnicity, and life stages? Any trends you are seeing or innovations you are excited about?
AI & The Feasibility of Hyper-Personalization
In the era of AI, how close are we to truly personalizing "beauty from within"? What are the greatest challenges and opportunities you see in developing ingredients and creating supplements truly tailored to an individual’s unique needs and biological data? Any other uses of AI in this space that you are excited about?
Sustainability & Clean Beauty 3.0
How is your organization addressing the demand for upcycling and "Clean Beauty 3.0"? Are there specific innovations in ingredients, technologies, or research methodologies that you believe the industry must adopt to meet the next generation of eco-conscious consumers?
The Next Phase of "Skinification"
We have seen the "skinification of hair," but where is the future of haircare headed? What "root cause" claims are consumers most seeking, and what is the next category you anticipate will undergo a similar "skinification" transformation?
Precision Solutions for Menopause
With the surge in perimenopause and menopause-specific products, how can we more accurately tailor solutions to women in these stages? What has the industry missed, and how can we better serve this demographic?
References and notes
In this Panel Discussion, several prominent companies within the food and nutraceutical ingredient industry have been invited to discuss about drivers and barriers of healthy lifestyle, focusing on global and regional consumer trends, scientific achievements, emerging delivery formats, use of AI technologies and the implementation of the United Nations sustainability goals.
1) One of the biggest shifts in beauty is the move away from purely cosmetic claims toward whole-person beauty, where appearance is connected to lifestyle, longevity, and overall wellbeing.
What we hear from the brands that we partner with is that their consumers are increasingly looking at skin, hair, and healthy aging through a wider biological lens, including stress, sleep, hormones, metabolism, inflammation, the microbiome, especially the gut-skin axis, and cellular aging. What I think is great is that beauty is no longer viewed as surface-level only. It is becoming a reflection of how well the body is functioning. And when you feel good, you look good.
Because of this, we are seeing more demand for clinically substantiated ingredients that support beauty outcomes through broader pathways. Brands are asking for studies that go beyond skin hydration or wrinkle appearance and connect beauty to mood, energy, fatigue, oxidative stress, inflammatory markers, metabolic health, immune resilience (senescence), and even cellular aging markers like telomere length, activity or attrition.
Over the next five years, I think beauty-from-within claims will become more science-backed and more holistic, with an even greater focus on natural ingredients that are plant-based. The focus will not only be on skin, hair, and nails, but also on longevity, resilience, and health at the cellular level.
Consumers are also more educated and skeptical. They want transparency, clean labels, and credible clinical substantiation. The brands that win will be the ones that can connect visible beauty, internal wellness, and strong scientific credibility.
2) The rise of GLP-1 medications has opened an important conversation around rapid metabolic change and visible beauty outcomes. Hair loss and changes in facial appearance, sometimes referred to as “Ozempic skin,” were not well defined early on, but emerging pharmacovigilance data and clinical observations are bringing these concerns forward (1).
What we understand today is that GLP-1 use may be associated with non-scarring hair loss, most often telogen effluvium and androgenetic alopecia.1 From a skin perspective, rapid weight loss, loss of muscle tone, inadequate protein intake, hydration challenges, and potential impacts on fibroblasts and collagen dynamics can all contribute to reduced skin elasticity and volume loss, especially in areas like the cheeks, temples, and under the eyes (2, 3). The result can be a more hollow, skeletonized or aged appearance, all of which are undesirable.
This creates a major opportunity for the nutricosmetic category to evolve beyond traditional beauty positioning and support individuals more holistically during periods of metabolic transition. In fact, many brands are now inquiring about GLP-1 supportive products and ingredients, including those that support skin integrity, stress resilience, sleep quality, inflammation balance, healthy aging, the gut microbiome, and metabolic wellness alongside aesthetic outcomes.
I also think consumers increasingly want solutions that help preserve vitality and confidence during these transitions, rather than focusing on appearance alone. The future of beauty and metabolic wellness will likely become much more interconnected, especially as research continues to expand around the gut-skin axis and microbiome.
3) What excites me most about the “well-beauty” movement is that consumers are recognizing how connected the body really is. Stress, poor sleep, inflammation, mood, metabolism, and gut health can all influence how we look, feel, and age.
The connection between beauty, wellness, and longevity continues to be an area of interest as the category moves toward a more holistic, inside-out approach to healthy aging. Plant-based bioactives are being explored for their potential role in this space, while formulation strategies are being evaluated to help address common challenges such as limited solubility, stability, and bioavailability. This research may help inform future innovation in beauty-from-within applications.
What makes this especially exciting is the clinical direction. Studies can evaluate benefits in both men and women over time, looking beyond traditional beauty-from-within endpoints to include areas such as cellular aging, inflammation, antioxidant status, metabolic health, and resilience.
Self-reported outcomes around skin appearance, aging perception, satisfaction, energy, fatigue, and vitality are also important. So, not just asking, “Does the skin look better?” But also asking, “Do you feel better, too?”
Personally, I think this is where the category is going: clinically substantiated, whole-person beauty solutions that connect visible appearance with internal wellness and healthy aging. For brands, this also creates opportunities to pair scientifically substantiated botanicals with established ingredients like collagen, soluble keratin, and hyaluronic acid to build more complete beauty and longevity platforms. The goal is to deliver benefits consumers can experience early, with outcomes that are felt from within and reflected in outer beauty.
4) For many years, topical beauty has been front and center in the nutricosmetic segment because it created rituals people enjoyed. For me, using topical beauty products is aspirational. I can often feel the benefits after just one use, whether that is smoother texture, better hydration, or simply feeling more refreshed. Plus, they give me the confidence to look as good on the outside as I feel on the inside.
That said, the ingestible beauty category is catching up and on. Consumers are looking for beauty-from-within products that are effective, but also enjoyable and easy to use every day. That is where functional beverages, gummies, powders, stick packs, and other modern formats become really exciting.
The challenge is that these products still have to deliver on the full consumer experience. Taste, texture, aroma, clean label, convenience, and compliance all matter, along with meaningful clinical dosing, ingredient stability, solubility, and shelf-life performance.
So, the opportunity is not just to create an ingestible beauty product. It is to create one that people actually want to take consistently and will deliver the clinically meaningful benefits consumers are looking for.
I think the future of ingestible nutricosmetics is very exciting, especially for companies that can combine the scientific efficacy with a sensory experience consumers will enjoy and can easily build into their daily routines.
This is also why we have recently introduced a dedicated Sustainability Manager within the company. The objective is to give sustainability a more structured framework, based on measurable tools, traceable data, and clear short-, medium-, and long-term objectives. In this way, sustainability becomes not only a value or a communication topic, but an operational and strategic process that can be monitored, improved, and integrated into ingredient development.
11) One of the biggest opportunities in women’s health and beauty is recognizing that menopause is not one single experience. Pre-, peri-, and post-menopause are biologically different stages, and women can experience them very differently depending on hormone patterns, stress, metabolism, lifestyle, and overall health.
That is what the industry has often missed. For too long, women’s formulas were treated as one-size-fits-all, when the needs of a woman in her early 30s may be very different from a woman navigating perimenopause, disrupted sleep, mood changes, hot flashes, or changes in sexual wellness and confidence. This is why precision matters. We need to design products around her life stage, her symptoms, and her desired outcome, not just a generic “women’s health” label.
That is where I think the category has an opportunity to evolve. Women are looking for solutions that work with their biology, not against it, and that support hormonal wellbeing in a more thoughtful and life-stage-specific way.
Rather than relying on a one-size-fits-all approach, the next generation of women’s health innovation should focus on supporting natural physiological pathways within healthy ranges, with solutions that are clinically substantiated and designed around real quality-of-life outcomes.
To me, this represents where the category needs to go: science-backed, stage-specific support that respects women’s biology and addresses the everyday experiences that matter most, from comfort and emotional wellbeing to sleep, vitality, and overall quality of life.
References and notes
Panelists
References and notes
- Gupta AK, Teasell EM, Economopoulos V, Mirmirani P. GLP-1 therapies and hair loss: A systematic review of current evidence and implications for counseling. Sci Prog. 2026 Apr-Jun;109(2):368504261444578. doi: 10.1177/00368504261444578. Epub 2026 Apr 17. PMID: 41998799; PMCID: PMC13100445.
- Paschou IA, Sali E, Paschou SA, Tsamis KI, Peppa M, Psaltopoulou T, Nicolaidou E, Stratigos AJ. GLP-1RA and the possible skin aging. Endocrine. 2025 Sep;89(3):680-685. doi: 10.1007/s12020-025-04293-w. Epub 2025 Jun 11. PMID: 40498168; PMCID: PMC12370548.
- Mozaffarian D, Agarwal M, Aggarwal M, Alexander L, Apovian CM, Bindlish S, Bonnet J, Butsch WS, Christensen S, Gianos E, Gulati M, Gupta A, Horn D, Kane RM, Saluja J, Sannidhi D, Stanford FC, Callahan EA. Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society. Am J Clin Nutr. 2025 Jul;122(1):344-367. doi: 10.1016/j.ajcnut.2025.04.023. Epub 2025 May 30. Erratum in: Am J Clin Nutr. 2026 Apr 7:101303. doi: 10.1016/j.ajcnut.2026.101303. PMID: 40450457; PMCID: PMC12612741.

















































