Scheda ingrediente
LIPINOVA®
Clinicamente testato Hyabest®,
il Sodio Ialuronato per il "Beauty from Within"
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INTRODUZIONE
LIPINOVA® is a unique, IP-protected ingredient concentrated in ‘Specialized Pro-resolving Mediators’ – also known as SPMs – that supports the body’s natural capacity to resolve inflammation.
SPMs are biosynthesized endogenously in the body from EPA and DHA omega-3 fatty acids, and have pro-resolution activity. LIPINOVA® therefore enables the creation of natural and safe immune-nutrition solutions targeted towards specific inflammatory health conditions and pain.
Learn more at: Lipinova.com
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SPMs are the active metabolites from EPA and DHA omega-3s biosynthesized endogenously and have an essential role in resolving inflammation and infection – enabling tissue healing and restoring the tissue environment to homeostasis. SPMs resolve inflammation by acting as stop signals in the inflammatory response, counter-regulating pro-inflammatory mediators and promoting the phagocytosis of pathogens and cellular debris by immune cells generated during the process, clearing up the medium and therefore enhancing tissue regeneration.
LIPINOVA® SPMs, provides an optimal fraction of standardized levels of monohydroxilated SPMs, performing as a catalyzer by activating the metabolic route of SPM biosynthesis and restoring depleted SPM levels.
MECCANISMO D'AZIONE
LIPINOVA® provides an optimal fraction of standardized levels of SPMs: 18-HEPE, 17-HDHA and 14-HDHA in rTG form in addition to EPA & DHA fatty acids.
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COMPOSIZIONE E SPECIFICHE TECNICHE
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EFFICACIA
LIPINOVA® safety and efficacy is proven in several published studies.
Results after supplementation with LIPINOVA indicated:
• An increased concentration of SPMs in blood
• A modulation of the immnune system towards resolution
• An improvement in outcomes such as pain
• No side effects
Study: Enriched marine oil supplements increase peripheral blood specialized pro-resolving mediators concentrations and reprogram host immune responses: a randomized double-blind placebo-controlled study
Conclusion: Supplementation with an enriched marine oil leads to an increase in peripheral blood SPM concentrations and reprograms peripheral blood cells, indicating a role for SPM in mediating the immune-directed actions of this supplement.
Study: Treatment with a marine oil supplement alters lipid mediators and leukocyte phenotype in healthy patients and those with peripheral artery disease
Conclusion: Short-term enriched marine oil supplementation dramatically remodels downstream lipid mediator pathways and induces a less inflammatory and more pro-resolution phenotype in circulating leukocytes and monocyte-derived macrophages.
Study: Early evidence of efficacy for orally administered SPM-enriched marine lipid fraction on quality of life and pain in a sample of adults with chronic pain
Conclusion: Oral supplementation with a fractionated marine lipid concentration standardized to 17-HDHA and 18-HEPE may improve quality of life, reduce pain intensity and interference, and improve mood within four weeks in adults with chronic pain.
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SICUREZZA
SPMs are endogenous compounds that are biosynthesized in our bodies from EPA and DHA in response to inflammation, to resolve it.
LIPINOVA® SPMs are naturally ocurring SPMs obtained from fish oil and have not presented any side effects so far in the studies conducted.
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IMPIEGO E PROCEDURA D’UTILIZZO
LIPINOVA® can be taken in soft gelatine capsules with a recomended dose of 1g/day.