The global demographic landscape is undergoing a profound transformation. The world population is rapidly aging, with the number of people aged 60 and older projected to double by 2050, reaching 2.1 billion (https://www.who.int/news-room/fact-sheets/detail/ageing-and-health ). This shift has led to a re-evaluation of aging, moving beyond merely extending lifespan to enhancing "healthspan" – the period of life spent in good health, free from chronic disease and disability. This paradigm defines the burgeoning "age better" trend, a holistic approach prioritizing physical vitality, mental acuity, and social engagement. Individuals are no longer content with passive aging; they actively seek to maintain independence, pursue passions, and contribute meaningfully to society well into their later years.

Today's population is more informed and proactive, viewing aging not as a decline but as a phase to be optimized. Their high expectations drive demand for solutions supporting critical functions: physical mobility and strength: maintaining muscle mass, bone density, and joint health to prevent falls and sustain an active lifestyle; cognitive function: preserving memory, focus, and overall brain health to stay mentally engaged; energy and vitality: combating fatigue and supporting cellular health for sustained energy levels; immune resilience: strengthening the body's defenses against external stressors; emotional well-being: managing stress and supporting mood for a balanced life.

This proactive mindset fuels significant investment in personal health, with many exploring nutrition, exercise, and supplementation to achieve their "age better" goals.

Indena's research into "age better" support focuses on cellular aging, body function, and healthy appearance. Effectively managing these aspects is crucial for healthy longevity, and Indena offers specific natural ingredients, validated through rigorous scientific studies, to support them. That’s why people’s golden aging starts today, thanks to Indena’s innovative products.

QUERCEFIT®, Quercetin Indena Phytosome®, slows down cellular aging to protect human innermost health and functionality

QUERCEFIT® is a nutraceutical ingredient formulated with the proprietary Indena Phytosome® technology, enhancing the benefits of quercetin. It has proven effective in managing cellular aging, or senescence – a cellular stress response triggered by exogenous insults (e.g., oxidative stress, toxic compounds, virus-infections) and physiological processes like aging.

Indena's scientific research supports QUERCEFIT® as a senolytic agent. A recent study using C. (Caenorhabditis) Elegans as a model organism showed significant results:

• Stress resistance (heat, oxidative stress): worms grown with QUERCEFIT® exhibited improved survival and pharyngeal muscle function after controlled oxidative stress, significantly outperforming unformulated quercetin (equimolar).
• Life span & health span: under thermal stress, QUERCEFIT®, similar to unformulated quercetin, increased the lifespan and health span of worms by approximately 50%, demonstrating its capacity to counteract age-associated decline in stress resistance.
• Senescence markers: only QUERCEFIT®, not unformulated quercetin, significantly promoted the expression of genes involved in antioxidant and detoxification responses (e.g., sod-3 and gst-4), encoding proteins related to longevity and stress.

UBIQSOME®, CoQ10 Indena Phytosome®, energizes body function right from its cellular foundation, improving strength and performance

UBIQSOME® is a unique CoQ10-based ingredient. Thanks to Indena Phytosome® technology, it promotes efficient delivery of coenzyme Q10 to target cells.

UBIQSOME® supports energy, skin health, and cardiovascular health:

• Energy: UBIQSOME® significantly increases muscle CoQ10 levels after 30 days of oral supplementation. In vitro, it increases CoQ10 in cells and mitochondria compared to unformulated CoQ10, favoring crucial cellular functions like oxygen consumption, ATP production, protein synthesis, and mitochondrial biogenesis, while reducing oxidative stress.
• Skin health: a scientific test showed UBIQSOME® is twice as efficient in delivering CoQ10 to human dermal fibroblasts compared to traditional CoQ10.
• Cardiovascular health: clinical evidences demonstrate UBIQSOME®'s efficacy in significantly improving endothelial function by +7% within 2 hours of administration. It provides multilevel support for cardiovascular health and acts as an effective adjuvant to counteract statin side-effects affecting muscle strength and performance.

PUREBKALE^® is an aqueous dry extract from Brassica oleracea seeds, which helps maintaining the healthy appearance of skin, thanks to anti-oxidant and detox action. It contains highly bioaccessible glucoraphanin — the natural precursor to sulforaphane (SFN), which bolsters the body's antioxidant defenses, shielding the skin from both oxidative stress and UV-induced damage. This fosters a visibly smoother, more radiant, and youthful complexion.

In vitro studies showed that glucoraphanin in PUREBKALE® is highly bioaccessible, with 100% conversion to sulforaphane when exposed to myrosinase enzyme. Furthermore, PUREBKALE® retains some natural myrosinase, contributing to sulforaphane formation. This makes PUREBKALE® a notable natural source of sulforaphane's antioxidant power for a bright and healthy appearance.

Sourced from a 100% Italian supply chain, Indena's raw material benefits from sustainable cultivation practices, resulting in superior biomass quality. The extract is also produced using only water, aligning with a sustainability commitment.

In conclusion, the "age better" trend is a fundamental shift in how society views and approaches aging. As a leader in the nutraceutical industry, with its focus on natural and preventive solutions, Indena is positioned as a vital partner in empowering individuals to achieve their goals of living longer, healthier, and more fulfilling lives.