Panel discussion on...
Pet Supplements
Greg Cumberford
Science Lead, Natures Crops International

Member of AgroFOOD Industry Hi Tech's Scientific Advisory Board

Microbial Homeostasis Across Species: Shaping Health Outcomes for Pets and Their Owners
1C) Yes, raising and caring for our pets as true family members has naturally helped people become better informed about their pets’ nutrition, optimal wellness, and factors affecting the quality of their healthspans (1). With the rise of AI, people can now easily ask and get answers to sophisticated questions about their pets’ health challenges. While doing so raises the bar on people’s expectations for transparency, integrity, and quality in the ingredients they feed to their pets, it doesn’t have to risk disappointment so long as ingredient providers transparently provide peer-reviewed science backing claimed benefits and prove the purity and integrity of their supply chains. Such standards are basic to building and maintaining consumer trust. In omega-3 nutrition, every cell in the mammal body (human, dog, horse) requires these polyunsaturated fatty acids for proper cell membrane function, hormonal balance, and inflammation response/signaling(2). Delivering a stable balance of these fatty acids without any risk of contaminants or rancidity, proven by robust certificates of analysis, empowers consumers to expect the same quality in their pets’ diets as for their own.
1L) Supporting healthy ageing for pets — keeping them active, fit, alert, flexible, and joyful — is a trend in itself, with innovation occurring in delivery formats (soft chews, sprays) and some ingredients that affect ‘whole body’ vs organ-specific support. Maintaining cardiovascular, mental, joint, skin (coat), and gut wellness (including healthy weight) are 5 key domains of healthy ageing. They are linked by hormonal signaling, glucose control, and stress response mechanisms inherent in every cell. Trending ingredients with natural anti-oxidants, anti-inflammatory, and mitochondrial support address ‘unhealthy ageing’ at its roots. This is when acute and systemic low-grade inflammation combine to impair any of these systems to a point beyond recovery through diet and lifestyle changes.
As recent research in biological vs chronological aging has shown, maintaining certain elevated intakes of nutrients like omega-3’s and vitamin D3 with exercise can measurably slow the body’s biological aging clock(4). Many individual legacy pet ingredients are aimed at symptomatic relief associated with aging — for example glucosamine/chondroitin for aging joints(5), blueberries or turmeric for oxidative stress, or pumpkin/beet fiber for constipation(6). Other trending ingredients support essential or rate-limited cellular function at every age, including NAD+(7), astaxanthin(8), and full-spectrum omega-369 fatty acids such as Buglossoides oil(9)— providing ‘building blocks’ for better energy metabolism, mitochondrial function, and a wider array of anti-inflammatory substrates supporting whole-body cell/tissue regeneration.
2C) We see a shift towards pet owners seeking multi-active functionality from the least amount of inactive carriers or excipients, using natural high purity ingredients that trace back to whole food sources. Rather than seeing long lists of inactive ingredients with chemical names, consumers want nutrient dense whole-form active ingredients. For example, Buglossoides arvensis seed oil, the richest source of plant-based ALA, SDA, and GLA fatty acids(10), is a single ingredient that serves as a multi-active blend. We also see a shift towards pet food contract manufacturers, many of whom were burned by the closures of the Peruvian anchovy harvest season in 2023-24, seeking to de-risk and simplify their supply chains to avoid both climate-induced and geo-political supply chain risks in conventional omega fatty acid sources. If a single plant-based omega-369 can functionally replace a multi-ingredient blend of fish, flax, and borage oils, it can avoid costly episodes and frustrated brand partners while reinforcing consumer brand loyalty.
2E) People want their pets to get key benefits associated with omega-3 supplementation: heart (fitness), joint (mobility), brain (mood/focus), and skin (coat luster) health. People want their pets to experience optimal active healthspans. Improved omega-3 status undoubtedly plays a role(2). However, many pet owners are also concerned about contaminants affecting omega-3 supplies from ocean sources and their sustainability in meeting global omega-3 demand(11).
Plant-based, regeneratively farmed omega-3 sources have an important complementary role to play. An innovative and relatively new entrant in pet nutrition is Buglossoides arvensis seed oil, which is nature’s richest omega-3 source (65%)(12). Buglossoides oil has the highest levels of omega-3 SDA and contains comparable anti-inflammatory GLA levels as evening primrose oil. It also has low levels of omega-6 linoleic acid, comparable to avocado and olive oils. SDA and GLA are not significantly present in fish or algal omega-3 oils. Buglossoides oil naturally contains more than twice the omega-3 content of natural fish oil. In head-to-head comparisons of Buglossoides oil to fish oil in research trials investigating anti-inflammatory effects (for example in joints(13) and on insulin sensitivity(14) or in mitochondrial respiration, Buglossoides oil’s unique fatty acids performed comparably to or better than fish oil.
Exciting new research in humans and animals is helping to explain why. This research effectively challenges the conventional view that marine EPA/DHA sources are superior to plant-based sources. For decades, veterinarians and nutritionists have understood that humans and pets gain better cardiovascular and cognitive health benefits from raising intakes of omega-3 EPA and DHA, omega-3’s found in fish oil. This is because plant-based sources traditionally only contain ‘precursor’ omega-3 ALA which although recognized as essential (the body cannot make it so it must come from the diet), does not raise circulating EPA and DHA levels as effectively as ‘preformed’ fish or algal sources. However, new highly sophisticated analytical techniques can now measure how quickly different plant sources of omega-3 convert to EPA/DHA in the tissues where omega-3’s matter the most: brain, liver, adipose. The new research shows that ALA’s actual conversion rate to DHA (thought to be <1% using blood-based measures) is at least 10 times higher in animals and humans than previous estimates(16). This means that omega-3 rich plant sources like Buglossoides oil, which provides the highest amount of naturally occurring ALA and SDA, can match fish oil for gaining typical omega-3 intake benefits, while offering more anti-inflammatory and hormonal balance benefits than can occur from flaxseed oil which contains no GLA.
4A) Key success factors are the same as for the human supplements sector:
- Trust, integrity, and transparency in supply chains — with no recalls
- Relevant peer-reviewed research backing claimed benefits for humans and animals
- Sustainable and regenerative production that doesn’t cost the Earth
- Free from chemical solvents, heavy metals, microbial pathogens
- Convenient, shelf stable, and palatable delivery forms that meet pets where they are
- Innovative, zero waste and/or upcycled ingredients and packaging
- Ingredient suppliers and consumer brands telling authentic origin stories that connect emotionally to why people love their pets and want to sustain their healthspan journeys in the first place
In this Panel Discussion, several prominent companies within the food and nutraceutical ingredient industry have been invited to discuss about drivers and barriers of healthy lifestyle, focusing on global and regional consumer trends, scientific achievements, emerging delivery formats, use of AI technologies and the implementation of the United Nations sustainability goals.
Panelists
References and notes
- Data from Ipsos Market Survey (2025) How humanizing pets is reshaping pet owners’ habits. https://www.ipsos.com/en-us/future/how-humanizing-pets-reshaping-pet-owners-habits#:~:text=Some%20of%20the%20ways%20that%20pet%20humanization,**Sustainability**%20*%20**Metabolic%20food**%20*%20**Therapeutic%20lines**
- Burron S, Richards T, Krebs G, Trevizan L, Rankovic A, Hartwig S, Pearson W, Ma DWL, Shoveller AK. (2024) The balance of n-6 and n-3 fatty acids in canine, feline, and equine nutrition: exploring sources and the significance of alpha-linolenic acid. J Anim Sci, Jan 3;102:skae143. https://doi.org/10.1093/jas/skae143.
- Carlisle C, Metzger BT, Tintle NL, Polley K, Jackson KH, Le Brun-Blashka S, Griffiths J, Harris WS. (2024) The Effects of Omega-3 Supplementation on the Omega-3 Index and Quality of Life and Pain Scores in Dogs. Animals (Basel). 2024 Oct 29;14(21):3108. https://doi.org/10.3390/ani14213108.
- Bischoff-Ferrari, H.A., Gängler, S., Wieczorek, M. et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. (2025) Nat Aging 5, 376–385. https://doi.org/10.1038/s43587-024-00793-y
- Bhathal A, Spryszak M, Louizos C, Frankel G. (2017) Glucosamine and chondroitin use in canines for osteoarthritis: A review. Open Vet J 7(1):36-49. doi: 10.4314/ovj.v7i1.6. Epub 2017 Feb 24. PMID: 28331832; PMCID: PMC5356289.
- Le Bon, M., Carvell-Miller, L., Marshall-Jones, Z., Watson, P., & Amos, G. (2023) A novel prebiotic fibre blend supports the gastrointestinal health of senior dogs. Animals, 13(20), 3291. https://doi.org/10.3390/ani13203291
- Aitken S, DVM. Unlocking the benefits: zesty paws® healthy aging supplement for dogs. (2023) PetMD, 11012023. https://www.petmd.com/dog/general-health/unlocking-benefits-zesty-paws-healthy-aging-supplement
- Khalsa D, VMD. Astaxanthin: protect aainst cancer, joint pain and more. (2024) Dogs Naturally 01162024. https://www.dogsnaturallymagazine.com/astaxanthin-for-dogs/#:~:text=If%20you%20want%20to%20feed,10%20times%20in%20a%20row?
- Williams K, Cumberford G. (2024) New UK-grown crop addresses fish oil challenges head on. Pet Food Processing 01052024. https://www.petfoodprocessing.net/articles/17714-new-uk-grown-crop-addresses-fish-oil-challenges-head-on#
- Baker EJ, Cumberford G, Hanaway P (2025) Recognizing the health benefits of plant-sourced omega-3 stearidonic acid: exploring its complementary role to preformed EPA/DHA. J Lipids, 2025; 0:1–8. https://doi.org/10.1002/lipd.12452
- Franklyn C (2022) Is fish oil good for dogs? dosage & side effects to know. The National Canine Cancer Foundation 07222022. https://wearethecure.org/is-fish-oil-good-for-dogs/
- Burt J (2025) Emerging dynamics in pet omega-3 nutrition. AgroFood Industry Hi-Tech 36:3;4. https://digital.teknoscienze.com/agrofood_industry_hi_tech_36_3_2025/pet_food_-_emerging_dynamics_in_omega-3_pet_nutrition
- Laevski et al (2024) Dietary omega‑3 fatty acids modulate the production of platelet‑derived microvesicles in an in vivo inflammatory arthritis model. Eur J Nutr, https://doi.org/10.1007/s00394-024-03397-9
- Lucchinetti et al (2024) The novel lipid emulsion Vegaven is well tolerated and elicits distinct giological actions compared with a mixed-oil lipid emulsion containing fish oil: a parenteral nutrition trial in piglets. J Nutr 2024. https://doi.org/10.1016/j.tjnut.2024.10.047
- Rotarescu RD et al (2024) Serum measures of docosahexaenoic acid (DHA) synthesis underestimates whole body DHA synthesis in male and female mice. J Nutr Biochem 131:109689. https://doi.org/10.1016/j.jnutbio.2024.109689.
Questions
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Ingredients companies - clinical data
A) What are the main scientific gaps that still exist in PET supplement development compared to human dietary supplements?
B) How important is species-specific research when selecting and developing active ingredients for pets? Can human data ever be sufficient?
C) Is the humanization of pets helping consumers make better-informed choices, or does it risk creating unrealistic expectations about supplement performance?
D) From an ingredient supplier’s perspective, which quality parameters (standardization, bioavailability, purity) are most critical for PET applications?
E) How are trends such as “clean label,” sustainability, and transparency influencing pet owners’ purchasing decisions in the PET supplement space?
F) What type of clinical evidence should realistically be expected to support PET supplement claims today?
G) Which types of claims are most likely to be misunderstood by consumers, and how can this risk be reduced through clearer substantiation and labeling?
H) What are the main methodological challenges in conducting clinical trials for companion animals, and how can they be addressed?
I) How reliable are owner-reported outcomes compared to veterinary assessments, and how should they be integrated into study design?
L) Have you noticed an increasing trend in the use of one (or more) ingredients for pet supplements formulated to promote healthy ageing?
Formulation
A) What are the biggest formulation challenges in PET supplements, particularly regarding palatability, stability, and dosing accuracy?
B) How do formulation choices (e.g., chews, powders, liquids) influence compliance and consistent use from a consumer perspective?
C) Do you see a shift toward simpler, single-ingredient formulations, or are multi-active blends still the dominant approach? Why?
D) How do species differences (dogs vs cats, size, age) influence formulation strategies?
E) Omega 3 alternatives for pet nutrition and sustainability: how do the innovative omega-3s for pet food stack up against their traditional fishy counterparts?
Regulation
A) How do regulatory frameworks for PET supplements differ between the EU and the US, and what challenges do these differences create for global brands?
B) Which types of claims represent the highest regulatory risk today, and which are more likely to be acceptable if properly substantiated?
C) Do you expect regulatory oversight of PET supplements to become stricter in the coming years? Why or why not?
D) What role should veterinarians play in guiding pet owners’ choices regarding PET supplements, and how can trust between brands, vets, and consumers be strengthened?
Open questions
A) Looking ahead 5–10 years, what will be the key factors determining the credibility and long-term success of the PET supplements sector?
B) In your view, what single change—scientific, regulatory, or educational—would most improve consumer trust in PET supplements over the next decade?
References and notes










