BlueCALM

Scutellaria lateriflora L. Dry extract 10% baicalin

Scutellaria lateriflora L. (Blue skullcap) is a perennial herb native to North America with a long traditional use to relieve anxiety and improve mood.

Excess cortisol is associated with many health concerns, such as anxiety, insomnia, depression, osteoporosis, and impairment of neuroendocrine and immune systems. BlueCALM® significantly inhibits cortisol release*, with a range from 58 to 91%.

In a clinical study**, BlueCALM® significantly improved sleep-wake balance in volunteers with mild-to-moderate primary insomnia; no adverse effects have been reported.

*Buccato, D.G.; Ullah, H.; De Lellis, L.F.; Piccinocchi, R.; Baldi, A.; Xiao, X.; Arciola, C.R.; Di Minno, A.; Daglia, M. In Vitro Assessment of Cortisol Release Inhibition, Bioaccessibility and Bioavailability of a Chemically Characterized Scutellaria lateriflora L. Hydroethanolic Extract. Molecules2024, 29, 586. https://doi.org/10.3390/molecules29030586

**Di Minno, A.; Morone, M.V.; Buccato, D.G.; De Lellis, L.F.; Ullah, H.; Piccinocchi, R.; Cordara, M.; Larsen, D.S.; Di Guglielmo, A.; Baldi, A.; et al. Efficacy and Tolerability of a Chemically Characterized Scutellaria lateriflora L. Extract-Based Food Supplement for Sleep Management: A Single-Center, Controlled, Randomized, Crossover, Double-Blind Clinical Trial. Nutrients2025, 17, 1491. https://doi.org/10.3390/nu17091491